« Ceramides are essential for our life on dry land. Major disturbances to their biosynthesis or transport could be lethal because of an extensive water loss. Even less pronounced alterations of the stratum corneum lipid composition and organization are associated with skin diseases such as atopic dermatitis, psoriasis and ichthyoses and could greatly affect the quality of life of the patients ».
« Formulations containing lipids identical to those in skin and, in particular, some ceramide supplementation could improve disturbed skin conditions ».
Coderch, Luisa, et al. « Ceramides and Skin Function ». American Journal of Clinical Dermatology, vol. 4, no 2, 2003, p. 107‑29. Source
At 24h post-application, skin hydration measured for Ceramide cream was significantly greater than that measured for all three of the reference moisturizers tested. Ceramide cream was also found to significantly decrease TEWL (P<0.001) over 24 hours, and was shown to be non-sensitizing to the skin of both adults and children and non-irritating to the skin, eyes and related eye area. »
« Ceramide cream increases skin hydration and improves barrier function which may make it suitable for use on dry skin ».
Spada, Fabrizio, et al. « Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems ». Clinical, Cosmetic and Investigational Dermatology, vol. 11, octobre 2018, p. 491‑97 Source
Ceramides were included in only one of the creams as this allows elucidating any advantage of these lipids in the formulation. (…) GACC cream was shown to give a larger effect on the skin hydration, likely to be because of the presence of ceramides ».
Machado, M., M. R. Bronze, and H. Ribeiro. "New cosmetic emulsions for dry skin." Journal of Cosmetic Dermatology 6.4 (2007): 239-242. Source
« (…) topical application of a lipid mixture, containing free fatty acid, cholesterol, and ceramide in an approximately equimolar ratio, allows normal barrier recover ».
Mao-Qiang, Man, et al. "A natural lipid mixture improves barrier function and hydration in human and murine skin." Journal of the Society of Cosmetic Chemists 47.3 (1996): 157-166. Source
« It is clear that dry skin consisting of low endogenous ceramide is convenient for exogenous ceramide passing ».
Kahraman, Emine, et al. "Recent advances on topical application of ceramides to restore barrier function of skin." Cosmetics 6.3 (2019): 52. Source
« These 12 reports showed that external ceramide-containing preparations can improve dry skin and barrier function in patients with atopic dermatitis ».
Kono, Takeshi, Yoshiki Miyachi, and Makoto Kawashima. "Clinical significance of the water retention and barrier function‐improving capabilities of ceramide‐containing formulations: A qualitative review." The Journal of Dermatology 48.12 (2021): 1807-1816. Source
