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EGF-1 Complex

Proteins used by the body as biological messengers responsible for initiating cellular renewal and repair.
Their use in cosmetics results in a significant increase in natural collagen production and a visible reduction in wrinkles.

Epidermal growth factor, or EGF, is a natural protein found in our plasma that helps maintain healthy skin structure by promoting cell regeneration. It stimulates the growth, proliferation, and differentiation of epidermal cells. This natural protein plays a vital role in maintaining skin firmness and elasticity. Unfortunately, its concentration tends to decline with age.

 

EGFs are frequently used because they have a multitude of properties: they stimulate the production of collagen, elastin and hyaluronic acid as well as skin hydration, they lighten dark spots, they reduce wrinkles, they improve blood circulation, they promote healing... The skin is soft, smooth, luminous, regenerated, toned and plump.

Its mode of action

When the cellular activator EGF binds to its specific cell surface receptor (EGFR), the receptor sends the message through a complex cascade of signals to the nucleus, the cell's control center. In the nucleus, the message is translated into various cellular activities such as protein production, increased genetic activity, and cell division. Skin growth factors regulate the expression of extracellular matrices (ECMs) such as collagen, elastin, and laminin.

By stimulating the production of collagen, elastin, and hyaluronic acid, EGF promotes skin rejuvenation. It reduces expression lines, makes skin firmer, and improves skin texture and appearance.

EGF also stimulates granulation tissue, which accelerates wound healing. It stimulates the proliferation of fibroblasts, keratinocytes, and vascular endothelial cells, which contribute to wound healing.

EGF reduces skin pigmentation and irregularities. The mechanism of action is still unclear as few studies have been conducted. However, EGF has been shown to have an anti-melanogenic effect by suppressing tyrosinase activity, reducing reactivity, its antioxidant effect, and regenerating the epidermal barrier of damaged tissue. In addition, several studies show that EGF reduces hyperpigmentation or melasma caused by lasers.

EGF also has an anti-inflammatory effect. Its mode of action is not yet clear, but it has been shown to interfere with the metabolism of arachidonic acid, an important intermediate involved in inflammation.

Use

EGF is widely used in cosmetics. Growth factors are often found in serums and masks, but also in face and eye creams. There are many growth factors, of which EGF (=Epidermal Growth Factor) is one of the most popular for topical application. However, due to their large size, growth factors have low transdermal diffusion efficiency. Therefore, a good formulation is necessary for the factors to penetrate the skin effectively.

Security

EGF is suitable for all skin types. However, its use is ideal for tired skin prone to dullness, wrinkles, and sagging. Furthermore, EGF is compatible with all the products in your daily skincare routine. However, you must be careful to follow these usage guidelines. Always test the product to see how your skin reacts (even if niacinamide is suitable for sensitive skin). In addition, it is important to respect the application doses. Today, after numerous independent scientific studies, no negative effects have been reported or observed from the use of EGF for cosmetic purposes. However, since they stimulate cell multiplication, EGF creams are not recommended for people suffering from skin conditions without medical advice.

Research

The results of in vitro and clinical studies suggest that cosmetic products containing growth factors, cytokines, matrikines, or matrikine-like peptides can enhance the production of collagen and other ECM molecules and promote skin rejuvenation ».

 

Aldag, Caroline, Diana Nogueira Teixeira, and Phillip S. Leventhal. "Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature." Clinical, cosmetic and investigational dermatology 9 (2016): 411. Source

Pastore, Saveria, et al. "The epidermal growth factor receptor system in skin repair and inflammation." Journal of Investigative Dermatology 128.6 (2008): 1365-1374. Source

Aldag, Caroline, et al. « Skin Rejuvenation Using Cosmetic Products Containing Growth Factors, Cytokines, and Matrikines: A Review of the Literature ». Clinical, Cosmetic and Investigational Dermatology, vol. 9, 2016, p. 411‑19. Source

Graham Carpenter and Stanley Cohen, “Epidermal Growth Factor”, THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 265, No. 14, Issue of May 15, pp. 7709-7712.1990 C 1990 by The American Society for Biochemistry and Molecular Biology Source

« Our results suggest that rhEGF is a potential renewal agent that acts to improve the migration and contraction of aged fibroblasts more efficiently than young fibroblasts under 3D culture conditions; thus, EGF may have valuable regenerative effects on aged skin ».

 

Kim, Daehwan, et al. « Epidermal growth factor improves the migration and contractility of aged fibroblasts cultured on 3D collagen matrices ». International Journal of Molecular Medicine, vol. 35, no 4, avril 2015, p. 1017‑25 Source

« Epidermal growth factors (EGF) are key factors in upregulating fibroblast proliferation and collagen synthesis in the skin – offering a promising future in cosmetic anti-ageing applications. However, their inherent instability and large size require dedicated product engineering for topical treatment ».

 

Eskens, Olivia, and Samiul Amin. "Challenges and effective routes for formulating and delivery of epidermal growth factors in skin care." International Journal of Cosmetic Science 43.2 (2021): 123-130. Source

EGF stimulated granulation tissue with accelerated wound closure and minimization of scars, compared with the group without treatment ».

 

Lee, Ji Hae, et al. "Evaluation of a highly skin permeable low-molecular-weight protamine conjugated epidermal growth factor for novel burn wound healing therapy." Journal of pharmaceutical sciences 102.11 (2013): 4109-4120. Source

« The EGF is effective in the advanced healing of skin wounds, according to the results of multiple investigations in severe cases ».

 

Miller-Kobisher, Blanca, Dubraska V. Suárez-Vega, and Gladys J. Velazco de Maldonado. "Epidermal growth factor in aesthetics and regenerative medicine: Systematic review." Journal of Cutaneous and Aesthetic Surgery 14.2 (2021): 137.Source

« GAIS scores showed an improvement in the melasma in 73.4% of subjects vs 13% improvement for the placebo side ».

 

Lyons, Alexis, Joseph Stoll, and Ronald Moy. "A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma." Journal of Drugs in Dermatology: JDD 17.9 (2018): 970-973. Source

Han, Jisu, et al. "The effect of epidermal growth factor-containing cream on the postinflammatory hyperpigmentation after Laser treatment." 프로그램북 (구 초록집) 64.2 (2012): 360-360. Source